Stoddart Mechanostereochemistry Group

 

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Stoddart Mechanostereochemistry Group
 

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Bill Goddard

Professor of Chemistry and Applied Physics
California Institute of Technology


Over the past decade, the Stoddart group, firstly at UCLA and now at NU and the Goddard group at CALTECH have collaborated on several research projects including molecular electronics, RGB systems and, very recently, radically based systems within mechanically interlocked molecules (MIMs). Their theoretical approach brings fundamental understanding to our experimental findings with high-level computational methods. The Goddard group has developed theoretical methods based on Density Functional Theory (DFT) to predict and understand the nature of MIMs. Their fearless and adventuresome theoretical approach has shed light on several challenging problems in the area of mechanostereochemistry. This fruitful collaboration has already resulted in a large number of high profile publications, including articles in Nature Chemistry, the Journal of the American Chemistry.

Website: Prof. William A. Goddard, III

Collaboration Publications: Publications

   
 

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Bartosz Grzybowski

Professor of Chemical and Biological Engineering
Northwestern University


Shortly after our move to Northwestern University, both the Stoddart group and the Grzybowski group initiated a fruitful multidisciplinary collaboration spanning the areas of nanoscience, self-assembly, and chemical systems engineering. This knightly collaboration brings together students in both the chemical engineering and chemistry departments, whilst simultaneously uniting current work underway in Northwestern's DOE Center for Nonequilibrium Energy Research Materials and the Center for the Chemistry of Integrated Systems. The collaborative work focusing on nanoparticulated switches, chemical networks, theory, templated nanoparticle self-assembly, and diffusion in reticular networks has already yielded numerous high impact publications in journals including communications and papers in Angewandte Chemie, The Journal of the American Chemical Society, Nano Letters, Nature Chemistry, and Nature.

Website: Grzybowski Group

Collaboration Publications: Publications

   
 

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Omar M. Yaghi

Professor, Department of Chemistry & Biochemistry
UCLA


The Stoddart and Yaghi groups began their collaboration in 2006, by attempting to bridge the fields of reticular chemistry and mechanostereochemistry. Their joint objective is to locate mechanically interlocked molecules (MIMs) precisely within the highly ordered crystalline lattices of metal-organic frameworks (MOFs). This highly challenging joint project which requires significant input from both groups, has culminated in a first publication in Science in 2009, describing the preparation of MOFs replete with crown ether appendages capable of sequestering the herbicide Paraquat from solution into the MOF crystal. Subsequent publications have followed in Chemical Communications and Chemistry–A European Journal. Buoyed by these initial successes, numerous collaborative efforts are ongoing, many of which involve group members traveling between the labs at NU and UCLA.

Website: Yaghi Laboratory

Collaboration Publications: Publications

   
 

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Jeffery I. Zink

Professor, Department of Chemistry & Biochemistry
UCLA


Over the past several years, the Stoddart and Zink groups have embarked on a productive and successful collaboration aimed at developing the area of mechanized mesoporous silica gel nanoparticles. The focus of our work together is to take molecular switches and use them as gating devices for cargo stored within the pores of the nanoparticles. These devices have captured a lot of interest as potential drug delivery vehicles, where therapeutic drugs can be stored within nanosized carriers and are then released upon meeting with a specific biological stimulus, e.g., pH, enzymatic cleavage. This collaboration involves several intersecting scientific areas that include nanoscale device fabrication, supramolecular chemistry, inorganic/organic synthesis and therapeutic drug delivery.

Website: Zink Group

Collaboration Publications: Publications

   

Copyright 2009 Stoddart Mechanostereochemistry Group. All rights reserved.

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2145 Sheridan Road
Evanston, IL 60208, USA
Phone: +1-847-491-3793
Fax: +1-847-491-1009