Nanoscale Borromean Links - The nontrivial link known as the Borromean rings has long been a source of endless fascination among artists, theologians, mathematicians, and scientists. The molecular construction of the Borromean Ring (BR) topology represents a formidable synthetic challenge as they consist of three mutually interlocked, yet noncatenated more...
Through its exploitation of noncovalent
bonding interactions and self-assembly processes, supramolecular assistance to
covalent synthesis has established itself as an efficient means of creating
molecules with nanoscale dimensions. For two decades, researchers have harnessed
the power of post-assembly covalent modification to produce an array more...
For over 40 years, the synthesis of
exotic molecules such as catenanes, rotaxanes, knots and Borromean rings with
aesthetically appealing and useful applications has been proceeding apace.
During the same period of time, the synthetic protocols employed by chemists
have evolved from being all statistical in the beginning, to progressively
Two of the central building blocks of
life are proteins and carbohydrates. The interactions between these two
disparate types of biomolecules play a role in numerous biological processes and
are critical to the onset, detection, and, potentially, prevention,of human
diseases such as cancer. Despite the importance of these interactions, the more...
The field of molecular electronics is
teeming with results, rationalizations and speculations from many research
laboratories. At the heart of this field is the drive to construct molecular
electronic devices that exhibit and take advantage of the rich set of molecular
properties which are under modular chemical control through contemporary more...
In recent years, developments in the
area of mechanically interlocked molecules designed to act as artificial
molecular switches and machines have proceeded apace. The potential applications
of these molecules varies widely and includes nanoelectronics and
nanoelectromechanical devices. Many different control stimuli have also been
Natural molecular machines, such as
ATP-synthase, myosin, kinesin, or dynein are complex and inspiring biological
assemblies whose structures and working mechanisms have been elucidated in a few
cases. These intriguing systems have prompted scientists to design and build
artificial molecular machines by mimicking their biological counterparts. more...
Two switchable, palindromically-constituted
bistable rotaxanes have been designed and synthesized (Appl. Phys. Lett.
2004, 85, 5391- 5393) with a pair of mechanically-mobile rings
encircling a single dumbbell. These designs are reminiscent of a “molecular
muscle” for the purposes of amplifying and harnessing molecular more...
In everyday life, macroscopic valves
control the flow of fluids and gases by opening and closing passageways. These
valves are essential regulatory devices that maintain the balance of fluids in
living beings as well as in macroscopic machines. Construction of such a device
on the nanoscale level requires (i) controllable switching elements, more...
Machines need power supplies to
generate mechanical movement. Just as macroscopic machines require macroscopic
energy sources, natural and artificial molecular machinery require nanoscale
power supplies to effect precise molecular movement. While macroscopic machines
do not move or work until energy is supplied to them for a specific function, more...