Stoddart Mechanostereochemistry Group





Stoddart Mechanostereochemistry Group

21 Feb 2014

Textbook Chemistry in Nature Chemistry - A simple abiotic model illustrating the fundamental way in which enzymes catalyze reactions in living systems is the result of a collaboration with Jay Siegel at Tianjin University. An article published in Nature Chemistry on 20 February 2014 describes the catalysis of the bowl–to–bowl inversion of corannulene inside a tetracationic receptor called ExBox which mimics the role of an enzyme in this process by binding the planar transition state of the corannulene more strongly than its bowl–shaped ground state. The authors demonstrate in this textbook example the tenents of enzyme catalysis as first discussed by Pauling, Koshland and Jencks. The article has been highlighted in C&EN and Chemistry World as well as in a News & Views by Larry Scott at Boston College in the March issue of Nature Chemistry.


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