Stoddart Mechanostereochemistry Group

 

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Stoddart Mechanostereochemistry Group
 

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Jianguo Cao

cao92128@yahoo.com

Graduate Student

Hometown: China

Joined group: 1996

Left group: 2001


Education:

PhD, Organic Chemistry, October 2001, University of California, Los Angeles.

MSc, Organic Chemistry, September 1988, Nanjing University, Nanjing, China.

Publications:

1. “Design, syntheses and SAR of low nM inhibitors targeting JAK2”, J. Cao, et al, 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007.

2. “Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine—a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays”, G. Noronha,a, K. Barrett, J Cao, E Dneprovskaia, R. Fine, X. Gong, C. Gritzen, J. Hood, X Kang, B Klebansky, G. Li, W. Liao, D. Lohse, C. C. Mak, A. McPherson, M. S. S. Palanki,a V. P. Pathak, J. Renick, R. Soll, U. Splittgerber, W. Wrasidlo, B. Zeng, N. Zhao, Y. Zhou, Bioorg. Med. Chem. Lett. 2007, 17, 602-608.

3. “Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 and its Active N-oxide Metabolite TG100855”, S. X. Hu, R. Soll, S. Yee, D. Lohse, A. Kousba, B. Zeng, X. Yu, A. McPherson, J. Renick, J. Cao, A. Tabak, J. Hood, J. Doukas, G. Noronha, M. Martin, Drug Metas. Dispos., 2007, 35, 929-936.

4. “Targeting Drug Resistant Mutations Using Novel Binding Interactions – Lessons Learned from Abl-T315I and their Implications in Drug Design”, G. Noronha, J. Cao, C. Chow, E. Dneprovskaia, L. Hwang, D. Lohse, C.C. Mak, A. McPherson, R.M. Fine, X. Kang, B. Klebansky, M.S.S. Palanki, V.P. Pathak, J. Renick, R. Soll and B. Zeng, Frontiers in Drug Design and Discovery, Vol. 3, Bentham Science Publishers, Illinois, 2007, 121-144.

5. “Discovery and Preliminary Structure–Activity Relationship Studies of Novel Benzotriazine Based Compounds As Src Inhibitors”, G. Noronha,a, K. Barrett, J Cao, E Dneprovskaia, R. Fine, X. Gong, C. Gritzen, J. Hood, X Kang, B Klebansky, G. Li, W. Liao, D. Lohse, C. C. Mak, A. McPherson, M. S. S. Palanki,a V. P. Pathak, J. Renick, R. Soll, U. Splittgerber, W. Wrasidlo, B. Zeng, N. Zhao, Y. Zhou, Bioorg. Med. Chem. Lett. 2006, 16, 5546-5550.

6. “Design, Syntheses and SAR of Inhibitors Targeting the T315I-ABL Mutation”, J. Cao, et al, 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006.

7. “Benzotriazine Inhibitors of Kinases”, G. Noronha,a, K. Barrett, J Cao, E Dneprovskaia, X. Gong, C. Gritzen, J. Hood, C. C. Mak, A. McPherson, V. P. Pathak, J. Renick, R. Soll, U. Splittgerber, W. Wrasidlo, B. Zeng, N. Zhao, PCT Int. Appl. WO2005096784, 2005.

8. “Threading/dethreading processes in pseudorotaxanes. A thermodynamic and kinetic study”, M. Venturi, S. Dumas, V. Balzani, J. Cao, J. F. Stoddart, New J. Chem. 2004, 28, 1032-1037.

9. “Working Supramolecular Machines Trapped in Glass and Mounted on a Film Surface”, S. Chia, J. Cao, J. F. Stoddart, J. I. Zink Angew. Chem. Int. Ed. 2001, 40, 2247-2451 (Front Cover).

10. “Controlled Switching of Surface Chemistry Using Tethered Molecular Machines”, J. Cao, J. F. Stoddart, J. O. Jeppesen, J. Perkins, D. I. Huber, B. C Bunker, J. G. Kushmerick, C. M. Matzke 221th ACS National Meeting, San Diego, CA, April 1-5, 2001.

11. “Azopyridinium-Containing [2]Pseudorotaxanes and Hydrazopyridinium-Containing [2]Catenanes”, P. R. Ashton, J. Cao, S. P. Newton, F. M. Raymo, J. F. Stoddart, A. J. P. White, D. J. Williams Eur. J. Org. Chem. 2001, 957-965.

12. “Self-Complementary [2]Catenanes and Their Related [3]Catenanes”, B. Cabezon, J. Cao, F. M. Raymo, J. F. Stoddart, A. J. P. White, D. J. Williams Chem. Eur. J. 2000, 6, 2262-2273.

13. “Molecular Shuttles by the Protecting Group Approach ”, J. Cao, G. R. L. Cousins, M. C. T. Fyfe, P. T. Glink, J. F. Stoddart J. Org. Chem. 2000, 65,1937-1946.

14. “A Self-Complexing [2]Catenane”, B. Cabezon, J. Cao, F. M. Raymo, J. F. Stoddart, A. J. P. White, D. J. Williams Angew. Chem. Int. Ed. 2000, 39, 148-151.

15. “Molecular Shuttles by the Protecting Group Approach”, J. F. Stoddart, J. Cao, G. R. L. Cousins, M. C. T. Fyfe, P. T. Glink, Books of Abstracts, 218th ACS National Meeting, New Orleans, LA, August 22-26, 1999.

 

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