Stoddart Mechanostereochemistry Group





Stoddart Mechanostereochemistry Group



Daniel P. Ferris

Postdoctoral Fellow

Hometown: San Diego

Joined group: 2013


Undergraduate - 2005 - University of Arizona - Major in Chemistry, Minor in Biochemistry and Cell Biology.
Graduate - 2011 - University of California, Los Angeles - Zink Research group - Specialized in materials development for biomedical applications.
Post-Doc - 2011-2013 - USC/Allergan Industrial Fellowship - Research in Formulations and Drug Development.


2012 Yanes, R. E.; Tarn, D.; Hwang, A. A.; Ferris, D. P.; Sherman, S. P.; Thomas, C. R.; Lu, J.; Pyle, A. D.; Zink, J. I.; Tamanoi, F. Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition Small, 2012, 9 (15), 697704.

2012 Lau, Y. A.; Henderson, B.; Lu, J.; Ferris, D. P.; Tamanoi, F.; Zink, J. I. Continuous Spectroscopic Measurements of Photo-Stimulated Release of Molecules by Nanomachines in a Single Cell. Nanoscale, 2012, 4 (11), 3482-3489.

2012 Clemens, D. L.; Lee, B.-Y.; Xue, M.; Thomas, C. R.; Huan M.; Ferris, D. P.; Nel, A.E.; Zink, J. I., Horwitz, M. A. Targeted Intracellular Delivery of Anti-tuberculosis Drugs to Mycobacterium Tuberculosis-infected Macrophages via Functionaluzed Mesoporous Silica Nanoparticles. Antimicrobial Agents and Chemotherapy, 2012, 56 (5), 2535-2545.

2011 Li, Z.; Likoko, J. N., Hwang, A.A., Ferris, D. P., Yang, S.; Derrien, G.; Charnay, C.; Durand, J. O.; Zink, J. I. Measurement of Uptake and Release Capacities of Mesoporous Silica Nanoparticles Enabled by Nanovalve Gates. J. Phys. Chem C, 2011, 115 (40), 1949619506.

2011 Ferris, D. P.; Lu, J.; Gothard, C.; Yanes, R.; Thomas; Olsen, J. C., Stoddart, J. F.; Tamanoi, F.; Zink, J. I. Synthesis of Biomolecule-Modified Mesoporous Silica Nanoparticles for Targeted Hydrophobic Drug Delivery to Cancer Cells. Small, 2011, 7 (13), 1816 1826.

2010 Thomas, C. R.; Ferris, D. P.; Lee, J.-H.; Choi, E.; Cho, M. H.; Kim E. S.; Stoddart J. F.; Shin J.-S.; Cheon J.; Zink J. I. Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles. J. Amer. Chem. Soc. 2010, 132 (31), 1062310625.

2010 Lau, Y. A.; Ferris, D. P.; Zink, J. I. Photo-driven nano-impellers and nanovalves for on-command drug release. Proc. of SPIE 2010, doi:10.1117/12.841175.

2009 Ferris D. P.; Zhao Y.; Khashab N. M.; Khatib H. A.; Stoddart J. F.; Zink J. I. Light-operated mechanized nanoparticles. J. Amer. Chem. Soc. 2009, 131 (5), 1686-1688.

2007 Orto, P. J.; Selby, H. D.; Ferris, D. P.; Maeyer, J. R.; Zheng, Z. Alcohol addition to acetonitrile activated by the [Re6(mu3-Se)8]2+ cluster core. Inorg. Chem., 2007, 46 (11), 4377.


My work focuses on the biochemical interface between cells and inorganic nanoparticles to achieve effective in vivo drug delivery. In order to accomplished these objectives, I am focusing on adapting past Stoddart supramolecular nano-valves for the biochemical environment to control the release of small molecule pharmaceutical agents from mesoporous silica nanoparticles. To achieve particle recognition and cancer cell selectivity, we are working to adapt established chemical methodologies to acquire site specific binding to maintain biomolecular integrity. Finally, we are adapting establish silica colloidal methodologies to modulate silica particle formation to enhance bio-circulation and size based cell selectivity. This will also allow us to adapt the nanoparticle platform to deliver a wider range of potential therapeutic agents for in-vitro and in-vivo selectivity.


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